This year’s NFL campaign has been incredibly unpredictable so far, with big hitters like the Packers and Buffalo Bills unable to live up to their billing as pre-season, Super Bowl favorites.

While this is great news for supporters, it’s continuing to create challenges for those who want to wager on the action and build lucrative bet slips. 

Sure, you can access the best football betting sites through the selection provided by betting.us to ensure you achieve optimal value for money, but picking viable winners is proving trickier than ever before. 

We’ll take a look at the best early NFL predictions and tips for week 13 while appraising some of the best online football sportsbooks for NFL wagering in a little more detail.

#1. Back the Chiefs to Beat the Bengals at -3

We’ll start with an exciting repeat of last season’s AFC Championship match, which saw the Bengals end the Chiefs’ 2022 campaign in overtime (before going on to lose to the LA Rams in Super Bowl LVI).

Little has changed from last season’s encounter, with the Chiefs still heavily reliant on quarterback Patrick Mahomes. He still remains the number-one favorite in the NFL MVP odds for 2023. He has certainly continued to put up points despite his charges getting little from their run game, while he’s played a critical role in the league’s top-scoring offense so far this term.

Given this and the fact that the Chiefs also have a point to prove to the Bengals, we’re expecting the latter to struggle in Kansas and fall narrowly short of repeating last season’s Championship win.

If you’re feeling really confident, you can even back the Chiefs at a handicap of -3, which may enhance the odds slightly and ensure that you pursue a higher return in relation to your stake.

#2. Back the Bills to Beat the Patriots of -5.5

Despite their challenging start to the season, the Bills remain a compelling watch, especially after the NFL Week 6 viewership where they delivered a strong audience to CBS.

The Bills also remain the favorites in the most recent Super Bowl odds, despite their enduringly patchy form and the fact that they’ve fallen to second in the AFC East division behind the Dolphins.

Also, the Bills earned a crucial, bounce-back win against the Browns in week 11, while there are signs that coach Bill Belichick is beginning to implement a turnaround in Buffalo’s fortunes.

So, although the Patriots boast an impressive run game, they’ll struggle to keep pace with an increasingly confident Bills’ side, particularly as starting quarterback Mac Jones is one of the worst in the league from a statistical perspective.

This is why you can back the Bills to win at a handicap of -5.5 with relative confidence, while we wouldn’t be surprised if the team also mounted a significant Super Bowl challenge this term.

#3. Back the Dolphins at the 49ers Over 46.5

This is another intriguing matchup and one that sees Mike McDaniel return to Levi’s Stadium with one of the most entertaining teams in the league in the form of the Miami Dolphins.

Much of this success is based on the form of legitimate MVP candidate Tua Tagovailoa, whose performances at quarterback have inspired a strong running game involving Jaylen Waddle and Tyrek Hill.

However, they’ll run into some serious opposition in the form of the San Francisco 49ers, who have played exceptionally well from an offensive perspective since a handful of their injured players have returned to health. 

With Christian McCaffery also in the electric form at running back, the 49ers are a tough side to beat and will surely play their own part in a potentially thrilling contest.

Overall, however, we think that the Dolphins hold the edge over their rivals, so we’re backing them to steal a potentially crucial win here.

Find the Best Football Betting Sites for NFL Wagering

As we’ve already touched on, the betting.us site compares and reviews the best online sportsbooks for football wagering stateside, taking a particularly close look at in-play wagering, welcome offers, and the full range of betting markets available.

We’d recommend using this resource before placing your NFL wagers for week 13, as this may help you to identify viable offers and the best value odds that enable you to make the most of your hard-earned bankroll.

Be particularly vigilant for operators that are offering enhanced odds promotions, particularly on specific NFL games and matchups!